METAL in PharMacEuTicAL

The simple inorganic platinum compound cis-diamminedichloroplatinum(II), also known as cisplatin, is one of the most important anticancer drug in clinical use. The discovery of its antitumoural activity by Barnett Rosenberg some 40 years ago opened a new area of anticancer research based on metal complexes.

In the Laboratory of Bioinorganic Chemistry, headed by Dr. Ang Wee Han, we are interested in taking the development of these metal complexes to a whole new level. Our research involves the study of the "metal" in pharmaceutical drugs for cancer therapy. Using rational drug design, we explore alternative strategies and analytical tools to develop viable chemotherapeutic agents based not only on platinum but also other metal centres.

Laboratory Group Members (Photo taken Aug 2015)

Featured Publications

What's New

Our paper entitled "Targeted Antibacterial Strategy Based on Reactive Oxygen Species Generated from Dioxygen Reduction Using an Organoruthenium Complex" has just been accepted in JACS Au as a letter. Congrats to all who contributed!

08 Sep 2021

Congrats to Dr Violet Lee Eng Yee for successfully defending her PhD! Her thesis title was "New Modes of Activation for Platinum(IV) Prodrugs for Controlled Anticancer Drug Delivery".

10 May 2021

Congrats to Dr Le Hai Van for successfully defending her PhD Thesis entitled "Investigation into the modulation of immune cells by metallodrugs".

07 May 2021

See the highlights of our article on Au(III)-metformin prodrugs on the FoS Research Website!

29 Apr 2021

Our paper entitled "A Cisplatin‐Selective Fluorescent Probe for Real‐Time Monitoring of Mitochondrial Platinum Accumulation in Living Cells" was featured as a Hot Paper and Frontispiece in this latest issue of Angew. Chem.! Congrats Jun Xiang!

19 Apr 2021

Violet's article "Strategy for Traceless Codrug Delivery with Platinum(IV) Prodrug Complexes Using Self-Immolative Linkers" has just been published on Inorg. Chem.

01 Mar 2021

Congrats to Dr Weng Cheng for successfully defending his thesis! His thesis was titled "Development of Bioorthogonal Chemistry using Coordination-Driven 3-Component Assembly Reaction Systems".

26 Jan 2021

We have moved to a new lab! Find us at NUS S9 Level 12.

11 Jan 2021

Congrats to Dr. Max Tham for successfully defending his thesis on 16 Dec! His thesis is titled "Understanding the Mechanism-of-Action of Platinum(II)-Based Type II ICD Inducers Through Purposeful Scaffold Modifications".

21 Dec 2020