Platinum
2021
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J. X. Ong, H. V. Le, V. E. Y. Lee, W. H. Ang*,
A Cisplatin‐Selective Fluorescent Probe for Real‐Time Monitoring of Mitochondrial Platinum Accumulation in Living Cells,
Angew. Chem. Int. Ed.,
2021,
60,
9264-9269
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V. E. Y. Lee, Z. C. Lim, S. L. Chew and W. H. Ang*,
Strategy for Traceless Codrug Delivery with Platinum(IV) Prodrug Complexes Using Self-Immolative Linkers,
Inorg. Chem.,
2021,
60,
1823–1831
2020
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G. Kim, H. L. Tan, R. Sundar, B. Lieske, C. E. Chee, J. Ho, A. Shabbir, M. V. Babak, W. H. Ang, B. C. Goh, W. P. Yong, L. Wang, J. B. Y. So,
PIPAC-OX: A Phase I study of Oxaliplatin-based Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Peritoneal Metastases,
Clin. Cancer Res.,
2020,
27,
1875
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B. S. Loh, W. H Ang*,
“Illuminating” Echinocandins’ Mechanism of Action,
ACS Cent. Sci.,
2020,
6,
1651-1653
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M. J. R. Tham, M. V. Babak,* and W. H. Ang.*,
PlatinER: A Highly Potent Anticancer Platinum(II) Complex that Induces Endoplasmic Reticulum Stress Driven Immunogenic Cell Death,
Angew. Chem. Int. Ed.,
2020,
59,
19070-19078
2019
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A. De Luca, L. J. Parker, W. H. Ang, C. Rodolfo, V. Gabbarini, N. C. Hancock, F. Palone, A. P. Mazzetti, L. Menin, C. J. Morton, M. W. Parker,* M. Lo Bello,* and P. J. Dyson*,
A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1,
Proc. Natl. Acad. Sci. U. S. A.,
2019,
116,
13943-13951
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V. E. Y. Lee, C. F. Chin and W. H. Ang*,
Design and investigation of photoactivatable platinum(IV) prodrug complexes of cisplatin,
Dalton Trans.,
2019,
48,
7388-7393
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M. V. Babak, Y. Zhi, B. Czarny, T. B. Toh, L. Hooi, E. K.-H. Chow, W. H. Ang,* D. Gibson,* and G. Pastorin*,
Dual-Targeting Dual-Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity (VIP),
Angew. Chem. Int. Ed.,
2019,
58,
8109-8114
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J. X. Ong, C. S. Q. Lim, H. V. Le, and W. H. Ang*,
A Ratiometric Fluorescent Probe for Cisplatin: Investigating the Intracellular Reduction of Platinum(IV) Prodrug Complexes,
Angew. Chem. Int. Ed.,
2019,
58,
164-167
2018
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K. G, Z, Lee, M. V. Babak, A. Weiss, P. J. Dyson, P. Nowak-Sliwinska,* D. Montagner,* and W. H. Ang*,
Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug,
Chemmedchem,
2018,
13,
1210-1217
2017
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S. Q. Yap, C. F. Chin, A. H. T. Thng, Y. Y. Pang, H. K. Ho,* and W. H. Ang*,
Finely Tuned Asymmetric Platinum(IV) Anticancer Complexes: Structure–Activity Relationship and Application as Orally Available Prodrugs (VIP),
ChemMedChem,
2017,
4,
300-311
2015
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J. X. Ong, J. Y. Yap, S. Q. Yap, W. H. Ang*,
Structure–Activity Relationship Studies on Rhodamine B-based Fluorogenic Probes and Their Activation by Anticancer Platinum(II) Compounds,
J. Inorg. Biochem.,
2015,
153,
272-278
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E. Y. D. Chua, G. E. Davey, C. F. Chin, P. Dröge, W. H. Ang* and C. A. Davey*,
Stereochemical Control of Nucleosome Targeting by Platinum-Intercalator Antitumour Agents,
Nucleic Acid Res. ,
2015,
43,
5284-5296
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D. Y. Q. Wong, W. W. F. Ong, W. H. Ang*,
Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes (VIP),
Angew. Chem. Int. Ed. ,
2015,
54,
6483-6487
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D. Y. Q. Wong, J. H. Lim, W. H. Ang*,
Induction of Targeted Necrosis with HER2-targeted Platinum(IV) Anticancer Prodrugs,
Chem. Sci.,
2015,
6,
3051-3056
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J. X. Ong, S. Q. Yap, D. Y. Q. Wong, C. F. Chin, W. H. Ang*,
Platinum(IV) Carboxylate Prodrug Complexes as Versatile Platforms for Targeted Chemotherapy (Special Issue),
Chimia,
2015,
69,
100-103
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L. Muzi, C. Ménard-Moyon, J. Russier, J. Li, C. F. Chin, W. H. Ang, G. Pastorin,* G. Risuleo*, A. Bianco*,
Diameter-Dependent Release of a Cisplatin Pro-Drug from Small and Large Functionalized Carbon Nanotubes,
Nanoscale,
2015,
7,
5383-5394
2014
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D. Y. Q. Wong, C. H. F. Yeo, and W. H. Ang*,
Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents,
Angew. Chem. Int. Ed.,
2014,
26,
6752-6756
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J. Li, A. Pant, C. F. Chin, W. H. Ang*, C. Ménard-Moyon, T. R. Nayak, D. Gibson, S. Ramaprabhu, T. Panczyk, A. Bianco*, G. Pastorin*,
In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes,
Nanomedicine: Nanotechnology, Biology and Medicine,
2014,
10,
1465-1475
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C. F. Chin,S. Q. Yap, J. Li, G. Pastorin*, and W. H. Ang* ,
Ratiometric Delivery of Cisplatin and Doxorubicin using Tumour-Targeting Carbon-Nanotubes Entrapping Platinum(IV) Prodrugs ,
Chem. Sci,
2014,
5,
2265-2270
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S. L. Yoong, B. S. Wong, Q. L. Zhou, C. F. Chin, J. Li, T. Venkatesan, H. K. Ho, V. Yu, W. H. Ang*, and G. Pastorin*,
Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin,
Biomaterials,
2014,
35,
748-753
2013
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T. Panczyk,* A. Jagusiak, G. Pastorin, W. H. Ang, J. Narkiewicz-Michalek ,
Molecular Dynamics Study of Cisplatin Release from Carbon Nanotubes Capped by Magnetic Nanoparticles,
J. Phys. Chem. C,
2013,
117,
17327-17336
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D. Montagner, S. Q. Yap, and W. H. Ang*,
A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold,
Angew. Chem. Int. Ed.,
2013,
52,
11785-11789
2012
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C. F. Chin, Q. Tian, M. I. Setyawati, W. Fang, E. S. Q. Tan, D. T. Leong, W. H. Ang*,
Tuning the activity of platinum(IV) anticancer complexes through asymmetric acylation,
J. Med. Chem.,
2012,
55,
7571-7582
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J. Li, S. Q. Yap, C. F. Chin, G. Pastorin*, W. H. Ang*,
Platinum(IV) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal,
Chem. Sci.,
2012,
3,
2083-2087
-
D. Y. Q. Wong, J. Y. Lau, W. H. Ang*,
Harnessing chemoselective imine ligation for tethering bioactive molecules to platinum(IV) prodrugs,
Dalton Trans.,
2012,
41,
6104-6111
2011
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J. Li, S. Q. Yap, S. L. Yoong, T. R. Nayak, G. W. Chandra, W. H. Ang, T. Panczyk, S. Ramaprabhu, S. K. Vashist, F.-S. Sheu, A. Tan, G. Pastorin*,
Carbon nanotube bottles for incorporation, release and enhanced cytotoxic effect of cisplatin,
Carbon,
2011,
50,
1625-1634
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C. F. Chin, D. Y. Q. Wong, R. Jothibasu, W. H. Ang*,
Platinum(IV) anticancer complex with novel modes of activity,
Curr. Top. Med. Chem.,
2011,
11,
2602-2612
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G. Zhu, M. Myint, W. H. Ang, L. Song, S. J. Lippard*,
Monofunctional Platinum–DNA Adducts Are Strong Inhibitors of Transcription and Substrates for Nucleotide Excision Repair in Live Mammalian Cells,
Cancer Res.,
2011,
72,
790-800
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K. Johansson, M. Ito, C. M. S. Schophuizen, S. Matthew, V. Heuser-Dahlström, J. Zhang, M. Shimoji, W. H. Ang, P. Dyson, A. Shibata, S. Shuto, Y. Ito, H. Abe, R. Morgenstern*,
Characterization of new potential anti-cancer drugs designed to overcome glutathione transferase mediated resistance,
Mol. Pharmacol.,
2011,
8,
1698-1708
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N. Graf, W. H. Ang, G. Zhu, M. Myint, S. J. Lippard*,
Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity,
ChemBioChem,
2011,
12,
1115-1123
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L. J. Parker, L. C. Italiano, C. J. Morton, N. C. Hancock, D. B. Ascher, J. B. Aitken, H. H. Harris, P. Campomanes, U. Rothlisberger, A. De Luca, M. Lo Bello, W. H. Ang, P. J. Dyson, M. W. Parker*,
Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation,
Chem. Eur. J.,
2011,
17,
7806-7816
2009
-
W. H. Ang, S. J. Lippard*,
Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site,
Chem. Commun.,
2009,
5820-5822
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W. H. Ang, W. W. Brown, S. J. Lippard*,
Preparation of platinated mammalian expression vectors incorporating site-specifically platinated-DNA lesions,
Bioconjugate Chem.,
2009,
20,
1058-1063
2007
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C. Hartinger*, W. H. Ang, A. Casini, L. Messori, B. K. Keppler, P. J. Dyson,
Mass spectrometric analysis of ubiquitin-platinum complex interaction in leading anticancer drugs: MALDI versus ESI,
J. Anal. At. Spec.,
2007,
22,
960-967
2005
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W. H. Ang, S. Pilet, R. Scopelliti, F. Bussy, L. Juillerat-Jeanneret*, P. J. Dyson*,
Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: Influence of the ligands on drug efficacies and uptake,
J. Med Chem.,
2005,
48,
8060-8069
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W. H. Ang, I. Khalaila, C. S. Allardyce, L. Juillerat-Jeanneret, P. J. Dyson*,
Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance,
J. Am. Chem. Soc.,
2005,
127,
1382-1383
